IL-22 and inflammation: Leukin' through a glass onion

IL 22 ( interleukin 22 )

Through a glass darkly: inhaled corticosteroids, airway inflammation and COPD.

It is 18 years since I last used the famous biblical phrase “through a glass darkly” to describe our uncertainties about the use of inhaled corticosteroids (ICS) in chronic obstructive pulmonary disease (COPD) patients [1]. Subsequently, an enormous amount of research has been undertaken, which has clarified the role of ICS in clinical management [2]. There is general agreement that these drugs...

Roles of IL-22 in Allergic Airway Inflammation

IL-23- and IL-17A-producing CD4(+) T cell (Th17 cell) axis plays a crucial role in the development of chronic inflammatory diseases. In addition, it has been demonstrated that Th17 cells and their cytokines such as IL-17A and IL-17F are involved in the pathogenesis of severe asthma. Recently, IL-22, an IL-10 family cytokine that is produced by Th17 cells, has been shown to be expressed at the s...

IL-22 and IL-17: An Overview

Many studies from recent years have shown that cytokines like IL-22, IL-17A, and IL-17F play a major role in both the defense against certain microbes and the development and maintenance of chronic inflammatory diseases. These mediators are often secreted by subpopulations of T-helper cells called Th17 cells and Th22 cells, respectively. This chapter provides an overview about the common and di...

Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A

IL-22 has both proinflammatory and tissue-protective properties depending on the context in which it is expressed. However, the factors that influence the functional outcomes of IL-22 expression remain poorly defined. We demonstrate that after administration of a high dose of bleomycin that induces acute tissue damage and airway inflammation and is lethal to wild-type (WT) mice, Th17 cell-deriv...